(Paperback - English - 9783319160641)
These notes originated as part of a lecture series on Stochastics in Biological Systems at the Mathematical Biosciences Institute in Ohio, USA. In this contribution the author uses multitype branching processes with mutation to model cancer. With cancer progression, resistance to therapy, the time of the first type $k$ mutation, and $\sigma_k$, the time of the first type $k$ mutation that founds a family line that does not die out, as well as the growth of the number of type $k$ cells. The last three sections apply these results to metastasis, ovarian cancer, and tumor heterogeneity. Even though martingales and stable laws are mentioned, these notes with example ..